A428T : Biochemical assays

The Saccharomyces cerevisiae pol2-G435C mutation mimicking human POLE-G420C does not affect the mutation rate.

• Shinbrot, E. et al. Exonuclease mutations in DNA polymerase epsilon reveal replication strand specific mutation patterns and human origins of replication. Genome Res 24, 1740-50 (2014). pubmed.ncbi.nlm.nih.gov/25228659/