A456P : Mutation rate in yeast

The Saccharomyces cerevisiae pol2-TLPT mutation mimicking human POLE-A456P causes a mutator phenotype in haploid strains when no wild-type POL2 is present.

• Lee, M. et al. Homologous recombination repair truncations predict hypermutation in microsatellite stable colorectal and endometrial tumors. Clin Transl Gastroenterol 11, e00149 (2020). https://pubmed.ncbi.nlm.nih.gov/32352724/