A465V : Mutation rate in yeast

The Saccharomyces cerevisiae pol2-A480V mutation mimicking human POLE-A465V causes a marginal increase in the mutation rate in haploid strains when no wild-type POL2 is present.

• Ostroverkhova, D. et al. DNA polymerase ε and δ variants drive mutagenesis in polypurine tracts in human tumors. Cell Rep 43, 113655 (2024) https://pubmed.ncbi.nlm.nih.gov/38219146/