C1058S : Mutation rate in yeast

The Saccharomyces cerevisiae pol3-C1056S mutation mimicking human POLD1-C1058S disrupts the interaction with the Pol31 subunit of DNA polymerase δ in the yeast two-hybrid system. There is no evidence that it increases the mutation rate.

• Sanchez Garcia, J., Ciufo, L.F., Yang, X., Kearsey, S.E & MacNeill S.A. The C-terminal zinc finger of the catalytic subunit of DNA polymerase δ is responsible for direct interaction with the B-subunit. Nucleic Acids Res 32, 3005-3016 (2004). https://pubmed.ncbi.nlm.nih.gov/15173383/