D402N : Mutation rate in yeast

The Saccharomyces cerevisiae pol3-D407N mutation mimicking human POLD1-D402N elevates the mutation rate in haploid strains when no wild-type POL3 allele is present.

• Murphy, K., Darmawan, H., Schultz, A., da Silva, E.F. & Reha-Krantz, L.J. A method to select for mutator DNA polymerase δs in Saccharomyces cerevisiae. Genome 49, 403–410 (2006). https://pubmed.ncbi.nlm.nih.gov/16699561/
• Herr, A. J. et al. Mutator suppression and escape from replication error-induced extinction in yeast. PLoS Genet 7, e1002282 (2011). https://pubmed.ncbi.nlm.nih.gov/22022273/