D402V : Mutation rate in yeast

The Saccharomyces cerevisiae pol3-D407V mutation mimicking human POLD1-D402V elevates the mutation rate in haploid strains when no wild-type POL3 allele is present.

• Jin et al. The 3’ →5’ exonuclease of DNA polymerase δ can substitute for the 5’ flap endonuclease Rad27/Fen1 in processing Okazaki fragments and preventing genome instability. Proc Natl Acad Sci USA 98, 5122-5127 (2001). https://pubmed.ncbi.nlm.nih.gov/11309502/