E1577A : Mutation rate in yeast

The Saccharomyces cerevisiae pol2-E1582A mutation mimicking human POLE-E1577A does not affect the mutation rate.

• Daee, D.L., Mertz, T.M., Shcherbakova, P.V. A cancer-associated DNA polymerase δ variant modeled in yeast causes a catastrophic increase in genomic instability. Proc Natl Acad Sci USA 107, 157-162 (2010). https://pubmed.ncbi.nlm.nih.gov/19966286/