E978G : Mutation rate in yeast

The Saccharomyces cerevisiae pol2-E991G mutation mimicking human POLE-E978G causes a mutator phenotype in haploid strains when no wild-type POL2 is present.

• Ostroverkhova, D. et al. DNA polymerase ε and δ variants drive mutagenesis in polypurine tracts in human tumors. Cell Rep 43, 113655 (2024) https://pubmed.ncbi.nlm.nih.gov/38219146/