G395S : Mutation rate in yeast

The Saccharomyces cerevisiae pol3-G400S mutation mimicking human POLD1-G395S elevates the mutation rate in haploid strains when no wild-type POL3 allele is present.

• Herr, A. J. et al. Mutator suppression and escape from replication error-induced extinction in yeast. PLoS Genet 7, e1002282 (2011). https://pubmed.ncbi.nlm.nih.gov/22022273/