L606M : Mutation rate in yeast

The Saccharomyces cerevisiae pol3-L612M mutation mimicking human POLD1-L606M elevates the mutation rate in haploid strains when no wild-type POL3 allele is present.

• Li, L., Murphy, K.M., Kanevets, U. & Reha-Krantz, L.J. Sensitivity to phosphonoacetic acid: a new phenotype to probe DNA polymerase δ in Saccharomyces cerevisiae. Genetics 170, 569-580 (2005). https://pubmed.ncbi.nlm.nih.gov/15802517/