R506H : Mutation rate in yeast

The Saccharomyces cerevisiae pol3-R511H mutation mimicking human POLD1-R506H causes a minor increase in the mutation rate in MSH6-deficient strains. It has no mutator effect in mismatch repair-proficient strains.

• Daee, D.L., Mertz, T.M., Shcherbakova, P.V. A cancer-associated DNA polymerase δ variant modeled in yeast causes a catastrophic increase in genomic instability. Proc Natl Acad Sci USA 107, 157-162 (2010). https://pubmed.ncbi.nlm.nih.gov/19966286/