S459F : Mutation rate in yeast

The Saccharomyces cerevisiae pol2-S474F mutation mimicking human POLE-S459F causes a mutator phenotype in a homozygous or heterozygous state.

• Barbari, S.R., Kane, D.P., Moore, E.A. & Shcherbakova, P.V. Functional analysis of cancer-associated DNA polymerase ε variants in Saccharomyces cerevisiae. G3 (Bethesda) 8, 1019-1029 (2018). https://pubmed.ncbi.nlm.nih.gov/29352080/