S459F : Tumor susceptibility and immune response in mouse models
Homozygous PoleS459F/S459F and heterozygous PoleS459F/+ mice show strong tumor susceptibility.
References
- Galati, M.A. et al. Cancers from novel Pole-mutant mouse models provide insights into polymerase-mediated hypermutagenesis and immune checkpoint blockade. Cancer Res 80, 5606-5618 (2020). https://pubmed.ncbi.nlm.nih.gov/32938641/