S478N : Mutation rate in yeast

The Schizosaccharomyces pombe pol3-C462N mutation mimicking human POLD1-S478N elevates the mutation rate in haploid strains when no wild-type pol3 is present. The analogous Saccharomyces cerevisiae pol3-S483N mutation elevates the mutation rate in a homozygous or heterozygous state.

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• Mertz, T.M. Characterization of cancer-associated DNA polymerase δ variants. Ph.D. thesis, University of Nebraska Medical Center (2015). https://digitalcommons.unmc.edu/etd_retro/2093/