V541M : Mutation rate in yeast

The Saccharomyces cerevisiae pol3-V546M mutation mimicking human POLD1-V541M increases the mutation rate in MSH6-deficient strains. It has no mutator effect in mismatch repair-proficient strains.

• Herr, A. J. et al. Mutator suppression and escape from replication error-induced extinction in yeast. PLoS Genet 7, e1002282 (2011). https://pubmed.ncbi.nlm.nih.gov/22022273/