POLD1 : D402A

This variant affects the catalytic amino acid residue in the exonuclease active site of DNA polymerase δ. It eliminates the exonuclease activity of the protein, elevates the mutation rate, and causes tumor susceptibility in model systems.

Biochemical assays Mutation rate in yeast Mutation rate in mouse cells Mutation rate in human cells Tumor susceptibility and immune response in mouse models